Present work demonstrates the ultrasound mediated synthesis of new Hexahydrospiro[indoline-3,3’-pyrrolizine]-2-one derivatives in excellent yields via [3+2] cycloaddtion reaction in regioselective manner under ul-trasonic irradiation. Multicomponent reaction of substituted 3-cinnamoyl-4-hydroxy-6-methyl-2H-pyran-2-one, isatin, L-proline was utilized for synthesis of spiro framework in regioselective manner at room temperature. All the synthesized hexahydrospiro molecules were characterized by 1H and 13C NMR, IR spectra, mass spectra and ele-mental analysis. Regioselective nature of reaction was explained on the basis of secondary orbital interactions. We have developed a very simple and facile methodology that has great importance in synthetic chemistry.