Synthesis of Novel Isoxazole by Click Chemistry Approach

Author(s): S. S. Pardeshi

Present study reports an alternatecatalytic click chemistry approach for synthesis regioselective 3,5-disubstituted isoxazoles from aldoxime and propargyl ester by heating at optimized temperatures. Copper catalyst was use for the reaction in Cu(I) state. Formation of 3,5-disubstituted isoxazole takes place via in situ [3+2] dipolar cycloaddition reaction. The key nitrile oxide intermediate is generated in situ from hydroxylmidoyl chloride.


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