Abstract

Synthesis, Characterization and Biological Screening of Quinoline Linked Oxadiazole Derivatives as Potent Antibacterial Agents

Author(s): Jayesh P. Jadhav 1*, Kokila A. Parmar 1, Shailesh C. Kotval 1,Tessy John 1, Vikaskumar R. Shukla 1, Margi A. Patel 1andBijal M. Patel

A series of ten derivatives of quinolin-8-yl[(5-aryl-1,3,4-oxadiazol-2-yl)sulfanyl]acetate was designed and derived through various steps. The structures of synthesized compounds were determined by IR, 1H NMR and Mass spectroscopy analyses. The antibacterial strength of synthesized compounds was evaluated by using bacterial strains Staphylococcus aureus,Bacillus subtilis, Pseudomonas aeruginosa andEscherichia coli where the study data reveals that some of the compounds have good antibacterial potential.

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