Synthesis, Characterization and Biological Evaluation of Novel N-alkylated 2-(4-bromophenyl)-1H-benzimidazoleDerivatives

Author(s): Deshmukh S. K.1and Sanjay Dashrath Vaidya2*

In present study O-pheylenediamine and 4–bromo benzoic acid were used as starting material and treated with poly phosphoric acid to obtained 2-(4-bromophenyl)-1H-benzimidazole.Using this compound,alkyla-tion done at the benzimidazole –NH position with different benzyl halide reagent leading to the functionalized de-rivatives. Newly synthesized derivatives (5a to 5g) have been evaluated on the basis of spectral and analytical data like melting point, IR, 1H-NMR and Mass spectroscopy.All the synthesized compounds were screened for their antimicrobial activity. This displayed some promising results towards testing organism in-vitro.


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