Stability Constant Study of Transition Metal Complexes with Pharma-cologically Active Nicotinamide and Alanineby pH Metric Technique

Author(s): D.D.Kayande1*,Shivaji Jadhav2, Mazahar Farooqui3andMegha Ra

The main objective of this research work is to carry out the stability constant study of ternary com-plexes of transition elements with nicotinamide and alanine.Formation of ternary complexes of transition elements like Fe(II), Co(II), Ni(II), Cu(II) and Zn(II) ofpharmacologically active Nicotinamide with Alaninewas studied by the pH-metric technique at 25±0.1°C in 70%(v/v) ethanol -water medium at 0.1M (NaClO4) ionic strength. The stability constants of the Nicotinamide and Alanine were calculated from the half integral method of potentiometric pH titra-tions data of solutions according to Irving and Rossetti’s method. The stability constants of these ternary complexes were evaluated and Order of stability constant found as Co (II) > Fe (II) > Cu (II) > Ni (II) > Zn (II).


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