Mesoporous silica nanoparticles are spine of nanotechnology; having exceptionally engaging proper-ties, for example, expansive surface region, high stacking limit, substantial pore volume, biocompatibility. Cross breed MSNs acquire when it joins with other natural/inorganic nanomaterials exhibit one of a kind cooperative energies and much more prominent adaptability.Mesoporous silica nanoparticles as medication transporter have turned into the new hot point in the field of biomedical application as of late. Mesoporous silica nanoparticles (MSNs) are broadly utilized as a conveyance reagent since silica has ideal concoction properties, warm dependabil-ity, and biocompatibility. The remarkable mesoporous structure of silica encourages viable stacking of medications and their consequent controlled arrival of the objective site. In this survey, we will concentrate on Hybrid Mesopo-rous Silica Nanoparticles (hMSNs) that having (theranostic) functionalities i.e., consolidate remedial and sympto-matic capacity, which make a shrewd nanocarrier for controlled arrival of corgo.At the point when joined with other natural/inorganic nanomaterials, the resultant natural/inorganic-MSN cross breeds show special cooperative energies and much more prominent adaptability. Now multi day's theranostic use of mesoporous silica nano-particles is one of the developing piece of medication conveyance framework to enhance the restorative exercises and to limit the related symptoms. We are trying to cover current updates related to formulation and recent advanc-es of nanoparticles.