Five metal chelates of Co(II), Ni(II), Cu(II), Zn(II) and Cr(III) ions with mixed ligands of a Schiff base: Namely, (E)-2-(4-(dimethylamino)benzylidene)amino)phenolderivedfrom4-dimethylaminobenzaldehydeand 2-aminophenol as main ligand (HL1) and 2-aminobenzoic acid as co-ligand (HL2) have been synthesized and characterized by using several physiochemical tools. An octahedral structure was suggested for all the chelates. Theantifungal activity the ligands and their mixed ligand chelatesagainst some path-ogenic fungi was studiedby usingagar well diffusion method. The obtained data showed that some of the chelates have most active againstA. niger,A. flavus, Alternaria alternata, Rhizopusstolonifer.