Abstract

A Strategic Development toward Tetrahydroquinoline Diversity: A Review

Author(s): Shyamal Mondal

etrahydroquinoline derivatives are a class of synthetic antibiotics with broad spectrum antibacterial as well as anti-malarial activities. The fused tetrahydroquinoline derivatives are also known to be effective in the treatment of autoimmune conditions (such as rhenumatoid arthritis) with their anti inflammatory effects. Among the numerous structurally diverse derivatives many tetrahydroquinolines show significant biological activity such as benzastatin, martinellic acid, and peniprequinolone etc. Hence, it is not surprising that this structural motif is also an important component in many of today’s pharmaceuticals. Nevertheless, the diversity of tetrahydroquinoline as well as their biological and pharmaceutical relevance is still motivating academic and industrial researchers to look for new and improved syntheses for tetrahydroquinoline based natural products. Clearly, a number of practical methods have been developed for the synthesis of tetrahydroquinolinesin the past century. More recently, especially transition metal catalysis has become a powerful tool for synthetic methodology but chemical and biological re-search has now presented a great challenge to synthesize and optimise highly efficient and cost-effective synthetic routes to some unique and novel biologically active substances. Pertinent structural, synthetic and semisynthetic studies reported in the open literature will be covered in this review


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